Kou's CV

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Curriculum vitae: Kousuke Hanada

Contents

Education

  • 2000, MVD (Veterinary) at the University of Nihon
  • 2003, PhD (Genetics) at the Graduate University for Advanced Studies / National Institute of Genetics (Supervisor: Prof. Takashi Gojobori)

Academic Experience

  • 4/2003-10/2005, Postdoctoral fellow at National institute of Genetics (Prof. Takashi Gojobori’s lab.)
  • 11/2005-4/2006, Postdoctoral fellow at University of Chicago (Prof. Wen-Hsiung Li’s lab.)
  • 5/2006-5/2007, Postdoctoral fellow, Michigan State University (Prof. Shin-han Shiu's lab.)

Publication

  • Tanaka Y, Hanada K, Hanabusa H, Kurbanov F, Gojobori T, Mizokami M.

Increasing Genetic Diversity of Hepatitis C Virus in Hemophiliacs with Human Immunodeficiency Virus Coinfection. Journal of General Virology in press.

  • Kubota R, Hanada K, Furukawa Y, Arimura K, Osame M, Gojobori T, and Izumo S.

Genetic stability of human T lymphotropic virus type I despite antiviral pressures by cytotoxic T lymphocytes. Journal of Immunology 2007 178:5966-5972.

  • Hanada　K, Hanada, K, Zhang, X, Borevitz, J. O., Li, W.-H., and Shiu, S.-H.

A large number of novel coding small open reading frames in the intergenic regions of the Arabidopsis thaliana Genome are transcribed and/or under purifying selection. Genome Research 2007 17:632-640.

  • Hanada　K, Tanaka Y, Mizokami M, Gojobori T and HJ Alter

A reduction in selective immune pressure during the course of chronic hepatitis C correlates with diminished biochemical evidence of hepatic inflammation. Virology 2007 361:27-33.

  • Hanada K, Gojobori T, Li WH

Radical Amino Acid Change versus Positive Selection in the Evolution of Viral Envelope Proteins. Gene. 2006 385:83-88.

  • Kiss I, Sami L, Kecskemite S, Hanada K

Genetic variation of the prevailing porcine respiratory and reproductive syndrome viruses occurring on a pig farm upon vaccination. Arch Virol. 2006 151:2269-2276.

  • Hanada K, Suzuki Y, Nakane T, Hirose O and Gojobori T

The origin and evolution of porcine reproductive and respiratory syndrome viruses Mol Biol Evol. 2005 22, 1024-1031.

  • Tanaka Y, Hanada K, Orito E, Akahane Y, Chayama K, Yoshizawa H, Sata M, Ohta N, Miyakawa Y, Gojobori T, Mizokami M.

Molecular evolutionary analyses implicate injection treatment for schistosomiasis in the initial hepatitis C epidemics in Japan. J Hepatol. 2005 42:47-53.

  • Mizokami M, Gojobori T, Hanada K.

Molecular evolutionary analysis of hepatitis C virus--detection of positive selective sites Nippon Rinsho. 2004 62:76-80. Review.

  • Hanada K., Gojobori T.

Reorganization of Genome Molecular Medicine 2004 41:101-109. Review

  • Hanada K, Suzuki Y, Gojobori T.

A Large Variation in the Rates of Synonymous Substitution for RNA Viruses and Its Relationship to a Diversity of Viral Infection and Transmission Modes. Mol Biol Evol. 2004 21, 1074-1080.

  • Tanaka Y, Hanada K, Mizokami M, Yeo AE, Shih JW, Gojobori T, Alter HJ.

A comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decades. Proc Natl Acad Sci U S A. 2002 26, 15584-15689.

  • Pignatelli S, Dal Monte P, Rossini G, Chou S, Gojobori T, Hanada K, Guo JJ, Rawlinson W, Britt W, Mach M, Landini MP.

Human cytomegalovirus glycoprotein N (gpUL73-gN) genomic variants: identification of a novel subgroup, geographical distribution and evidence of positive selective pressure. J Gen Virol. 2003 84, 647-655.

  • Imanishi T, ..., Hanada K, et al. (156 co-authors).

Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones. PLoS Biol. 2004 2(6):e162.

Presentation in International Conference

T-A Endo, K Hanada and T Gojobori A map of viruses on higher eucaryote Symposium on Evolutionary Genomics(shizuoka) 2001,Nov

K Hanada and T Gojobori Search for human genomic regions homologous to viral genes H invitational meeting (Tokyo) 2002, Apr

K Hanada, T-A Endo and T Gojobori Search for human genomic regions homologous to viral genes Molecular Evolution 2002 (Italy) 2002, Jun

K Hanada, Y Suzuki and Takashi Gojobori Whole genome sequence search for human DNA regions homologous to retrovirus elements HUGO (Human Genome Meeeting - HGM2003) (Mexico) 2003, Apr

K Hanada, Xu Zhang, JO,Borevvitz, WH Li and SH shiu A large number of novel somall open reading frames (sORF) in the intergenic regions of the Arabidopsis thaliana genome are transcripted or under purifying selection Midwest Quantitative Biology Conference (USA, MI) 2006, Sep

Research Interest

  • Viral evolution
  • Co-evolution between viruses and eukaryotes
  • Development of method for identifying positive selection
  • Comparative genomics
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